Find the Right Peptide
for Your Goal

Semaglutide

Semaglutide is a GLP-1 receptor agonist originally developed for type 2 diabetes and later approved for chronic weight management (Wegovy). It works by slowing gastric emptying, reducing appetite, and modulating the reward pathways for food. Clinical trials show 15–20% body weight reduction over 68 weeks with weekly subcutaneous dosing.

Available through most major telehealth clinics as a compounded injectable — typically at a fraction of the brand-name cost. NextGenPeps also carries it as a research compound at competitive pricing.

Tirzepatide

Tirzepatide is a dual GIP/GLP-1 agonist (Mounjaro/Zepbound) that consistently outperformed semaglutide in head-to-head trials — showing up to 22.5% weight loss. The dual mechanism provides stronger appetite suppression and better glycemic control. Higher cost than semaglutide but increasingly available through telehealth.

AOD-9604

AOD-9604 is a modified fragment of human growth hormone (hGH176-191) that mimics the fat-metabolizing effects of HGH without affecting blood sugar or IGF-1 levels. It stimulates lipolysis (fat breakdown) and inhibits lipogenesis. Milder than GLP-1 agonists but useful for targeted fat loss without appetite suppression. Currently available through Defy Medical telehealth.

Cagrilintide

Cagrilintide is a long-acting amylin analogue currently in clinical trials as a combination therapy with semaglutide (CagriSema). Amylin complements GLP-1 action by slowing gastric emptying and promoting satiety through a different receptor pathway. Available as a research compound through NextGenPeps — primarily used by experienced self-experimenters familiar with the trial data.

Retatrutide

Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously — showing 24% weight loss in Phase 2 trials, the highest of any single agent studied. Still in late-stage clinical trials as of 2026 and not yet commercially available through telehealth clinics. Limited research availability; follow trial progress closely.

CJC-1295 + Ipamorelin

The most widely prescribed peptide stack in telehealth. CJC-1295 is a GHRH (growth hormone releasing hormone) analogue that extends the GH pulse, while Ipamorelin is a selective GHRP (growth hormone releasing peptide) that triggers GH release with minimal cortisol or prolactin side effects. Used together, they create a sustained, synergistic GH pulse that supports lean mass gains, fat loss, improved sleep, and faster recovery.

Available at Defy Medical, Maximus, Marek Health, and Limitless Alt Med. Both peptides are also sold separately through NextGenPeps for research use.

Ipamorelin

Ipamorelin is the cleanest growth hormone secretagogue available — it produces a selective GH pulse without raising cortisol, prolactin, or ACTH. Preferred for beginners and those who want GH benefits with minimal side effects. Often used solo before adding CJC-1295 to the protocol. Available at Defy Medical and Marek Health via telehealth.

MK-677 (Ibutamoren)

MK-677 is an oral growth hormone secretagogue that mimics ghrelin, triggering GH and IGF-1 release. Unlike injectable secretagogues, it's taken orally once daily — making it extremely convenient. Clinical studies show significant increases in IGF-1 and lean mass over 24+ weeks. Currently available research-grade only; check vendors for current availability.

BPC-157

Body Protection Compound-157 is a 15-amino acid peptide derived from a gastric protein. It's among the most extensively studied healing peptides, with research showing accelerated tendon, ligament, muscle, and gut repair. It upregulates growth factor receptors and promotes angiogenesis (new blood vessel formation) at injury sites. Available via Defy Medical, Marek Health, and Limitless Alt Med telehealth, and in both oral and injectable forms from NextGenPeps.

TB-500 (Thymosin Beta-4 Fragment)

TB-500 is the synthetic version of a naturally occurring peptide that regulates actin — a key protein in cell structure and mobility. It promotes cell migration to injury sites, reduces inflammation, and accelerates healing in soft tissue, tendons, and ligaments. Often stacked with BPC-157 for synergistic recovery effects. Available at Defy Medical and Marek Health via telehealth.

Thymosin Beta-4 (TB-4)

The full Thymosin Beta-4 molecule (as opposed to the TB-500 fragment) provides broader immune modulation and tissue repair signaling. Marek Health carries TB-4 as a telehealth option. Note: Thymosin Alpha-1 is a completely different compound (immune support) — confirm you're getting TB-4 when ordering.

GHK-Cu (Copper Peptide)

GHK-Cu is a naturally occurring copper-binding peptide with potent wound-healing, anti-inflammatory, and collagen-synthesis properties. It activates over 31 genes related to tissue remodeling and has documented effects on skin repair, nerve regeneration, and antioxidant activity. Available at Defy Medical, Marek Health, and Limitless Alt Med via telehealth, and from NextGenPeps research.

NAD+

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme in every cell, central to ATP production and DNA repair. NAD+ levels decline ~50% between ages 40 and 60. Injectable NAD+ (subcutaneous) delivers the compound directly into circulation, bypassing the degradation that limits oral forms. Effects include improved energy, mental clarity, reduced fatigue, and support for cellular longevity pathways. Available at most major telehealth clinics and from NextGenPeps.

MOTS-C

MOTS-C is a mitochondria-derived peptide that activates AMPK — the cellular "energy sensor" — and promotes metabolic flexibility. Originally studied for exercise adaptation and metabolic health, it shows promise for sustained energy production, insulin sensitivity, and anti-aging effects. Available at Defy Medical and Marek Health via telehealth.

Semax

Semax is an ACTH(4-7)PGP analogue originally developed in Russia for stroke recovery and cognitive enhancement. It increases BDNF levels, supports dopaminergic transmission, and provides a clean energy and focus enhancement without stimulant side effects. Available from NextGenPeps as a research compound.

Semax

Semax is the most evidence-backed cognitive peptide currently available for research use. As an ACTH analogue, it increases BDNF by 2–4× in the hippocampus and prefrontal cortex — brain regions critical for learning and memory. Users report improved focus, faster recall, and reduced mental fatigue. No significant tolerance, dependency, or stimulant-type side effects reported.

Selank

Selank is a synthetic analogue of tuftsin with anxiolytic and nootropic properties. It reduces anxiety and mental fog while enhancing focus — making it popular for high-stress cognitive work. Unlike benzodiazepines, it carries no sedation or dependency risk. Available from NextGenPeps research.

Dihexa

Dihexa is a hexapeptide derived from angiotensin IV that acts as a potent BDNF mimetic — reportedly 10 million times more potent than BDNF itself at crossing the blood-brain barrier. Research-stage only; gaining traction in neuroplasticity and cognitive enhancement communities. Check current research vendor availability.

Pinealon

Pinealon is a tripeptide (Glu-Asp-Arg) derived from the pineal gland. It targets brain and neuroendocrine tissue, with research suggesting neuroprotective effects and support for circadian rhythms and cognitive longevity. Used in Russian anti-aging protocols. Available from NextGenPeps.

NAD+ (for cognition)

Beyond energy, NAD+ plays a critical role in neuronal health — supporting DNA repair in brain cells, SIRT1 signaling for cognitive longevity, and mitochondrial function in neurons. Patients on NAD+ protocols frequently report improved mental clarity as a secondary benefit. Available at most telehealth clinics.

PT-141 (Bremelanotide)

PT-141 is the only peptide with direct, central-acting sexual desire enhancement. Unlike PDE5 inhibitors (Viagra/Cialis) that work peripherally, PT-141 activates melanocortin receptors in the brain to increase sexual motivation in both men and women. FDA-approved as Vyleesi for women; widely prescribed off-label for men. Available at Defy Medical, Marek Health, Limitless Alt Med, and from NextGenPeps research.

Kisspeptin

Kisspeptin is a hypothalamic neuropeptide that regulates GnRH pulsatility, which in turn drives LH, FSH, and ultimately testosterone and estradiol production. It supports libido through hormonal optimization rather than direct activation. Available via Defy Medical telehealth — particularly useful for men with secondary hypogonadism or women with hormonal libido issues.

Gonadorelin

Gonadorelin is a GnRH analogue that stimulates LH and FSH production, preserving natural testosterone production and testicular size in men on TRT. Often co-prescribed with testosterone by clinics like Marek Health. Essential for men who want to maintain fertility on TRT protocols.

HCG (Human Chorionic Gonadotropin)

HCG mimics LH, directly stimulating testicular Leydig cells to produce testosterone and maintain spermatogenesis. Used alongside TRT to preserve testicular function and prevent atrophy. Available at Defy Medical and Marek Health via telehealth and from NextGenPeps research.

Testosterone (TRT)

Testosterone replacement therapy is the foundation of male sexual health optimization. Low testosterone is a primary driver of reduced libido, ED, and fatigue. Available at Maximus, Marek Health, Limitless Alt Med, PeterMD, and Defy Medical — each with different protocols, pricing, and lab requirements. See our clinic comparison table for full details.

NAD+

NAD+ is the most studied longevity molecule available through telehealth today. Declining NAD+ is directly implicated in virtually every hallmark of aging — impaired DNA repair, mitochondrial dysfunction, chronic inflammation, and reduced sirtuins activity. Injectable NAD+ restores cellular levels rapidly, with documented improvements in energy, cognitive function, inflammation markers, and potentially longevity-related gene expression. Available at most major clinics and from NextGenPeps.

Epithalon (Epithalamin)

Epithalon is a tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland with documented telomere-extending properties. It activates telomerase, the enzyme that lengthens telomeres — a key marker of cellular age. One of the most studied anti-aging peptides in Eastern European research literature, with over 40 years of data. Available at Defy Medical via telehealth and from NextGenPeps research.

MOTS-C

MOTS-C is encoded in mitochondrial DNA — making it unique among peptides. It activates AMPK and the SIRT1 pathway, mimicking the metabolic effects of caloric restriction and exercise. Research in aging models shows improvements in metabolic health, insulin sensitivity, and longevity-related gene expression. Available at Defy Medical and Marek Health via telehealth.