A dual GIP/GLP-1 receptor agonist (Mounjaro/Zepbound) that outperformed semaglutide in trials, producing up to 22.5% average body weight loss — the highest of any approved drug to date.
| Provider | Type | Price | Review | Link |
|---|---|---|---|---|
| MYRNK | Telehealth | $129+/mo | Read review | Get Started → |
| MadeMed | Telehealth | $199/mo | Read review | Get Started → |
| Marek Health | Telehealth | $166/mo | Read review | Get Started → |
| Limitless Alt Med | Telehealth | $115–$275/mo | Read review | Get Started → |
| NextGenPeps | Research | $73 / 10mg | — | Visit Site → |
Telehealth = physician-prescribed. Research = for research use only, no prescription required. Learn the difference →
Tirzepatide is a novel dual agonist that simultaneously activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors. Marketed as Mounjaro for diabetes and Zepbound for obesity, it represents the next generation of weight loss pharmacology — combining two complementary hormonal pathways to amplify satiety and metabolic benefits beyond what either agonist achieves alone.
The SURMOUNT-1 trial (n=2,539) demonstrated 22.5% mean body weight loss at the highest dose (15mg/week) over 72 weeks — the largest weight reduction ever recorded in a phase 3 drug trial for obesity. In a direct head-to-head trial (SURMOUNT-5), tirzepatide produced 47% greater weight loss than semaglutide. Cardiometabolic benefits including blood pressure, triglycerides, and insulin resistance also showed superior improvement.
Tirzepatide users typically experience faster and more pronounced appetite suppression than semaglutide. The titration schedule starts at 2.5mg/week and advances every four weeks. Nausea is the most common early side effect and generally resolves after the first month. Compounded tirzepatide via telehealth offers cost savings of 60–80% versus brand-name Zepbound.
Tirzepatide requires a physician prescription. Telehealth clinics offering compounded versions provide the most cost-effective access route. Research vendors (NextGenPeps) list it under the compound code GLP-TZ.